Here's another nifty short line you can build with your train simulator. This one's a freelance job and it's fully described in the May issue of Model Railroader. The layout as built is in On30 gauge (O scale using HO gauge track), but is perfectly adaptable to simulation. Simulators give us the chance to stretch the distances, which I would definitely do in order to get more running room.
The layout, called the Bay Point & Diablo RR, is by Bill Wilson, who fashioned it in a San Fancisco Bay setting in the early 20th Century. It could be adapted to other climbs, especially those with some water.